Background: Interests in natural products are being subjected to scientific method of testing. The use of Aloe Vera cuts across barriers of time and culture in the treatment of a broad range of illnesses. The basis of its reputation resides mainly with steadfast belief in claims of its cuRATive properties, but without hard scientific evidence.Materials and Methods: Thirty three adult MALE RATs were divided into three groups. Experimental groups received Aloe Vera aqueous leaf extract orally for 60 days in two different sublethal doses; of 60 mg/kg, and 120 mg/kg body weight of aqueous extract of Aloe Vera respectively; while, the control received equal volume of distilled water for the duRATion of a complete spermatogenic cycle.Results: The administRATion of the aqueous extract of of Aloe Vera aqueous leaf extract resulted in a significant decrease in testis weight in the two experimental groups in comparison to the control group but had no effect on body or organ weight. The extract of this plant caused a decrease of the following in the two experimental groups, compared to the control group: sperm count, motility and normal morphology, pregnancy RATe and diameter and wall thickness of seminiferous tubules. Also, distortion of morphology of the seminiferous tubules and arrest in spermatogenesis was observed in the experimental groups. In addition, the percentage of sperm with damaged chromatin integrity was significantly higher in the two experimental groups.Conclusion: From the present study, we can conclude that Aloe Vera aqueous leaf extract acts as an anti-fertility agent RATher than other herbalists.

Introduction: Clobazam is an anticonvulsant drug. Its side effects on reproductive functions have not been sufficiently studied. This study was designed to evaluate the effect of clobazam on pituitary-gonad axis and spermatogenesis in adult MALE RATs.Materials and Methods: 40 adult MALE RATs wistar strain were randomly divided into five groups. Animals in group1 (Control group) were injected with any treatment. Animals in group2 (Sham group) received the three-component solvent (propylenglycol, ethanol and distilled water in a RATio of 5: 2: 3) in a corresponding volume, i.e.1ml/kg.bw.Animals in groups 3, 4, and 5 received clobazam (dissolved in solvent), respectively, in doses of 2.5, 5, and 10 mg/kg.bw/day i.p. for 21 days. At the end of the study, blood gonadotropins (LH and FSH) levels as well as testosterone of RATs in five groups were determined. The animals were sacrificed, then, spermatogram and histological changes of their testes were studied under light microscope.Results: The results show that in clobazam treated groups, particular experimental group 3, blood testosterone levels were significantly decreased as compared to the control group. Plasma concentRATions of LH, FSH assayed and there were no significant differences among the clobazam treated groups as compared with control group. Body weight in clobazam treated relatively increased. However, sperm density and testes weight were not different from those of the control group.Conclusion: These findings indicate that clobazam has a relative suppressive influence on reproductive function in RATs. We suggest that clobazam directly affects production of testosterone in leydig cells or centrally increased estradiol biosynthesis subsequently lowered testosterone levels by negative feedback.